ChansonRolandV6, Main, Exploration, bibRecord, 000835

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

Identifieur interne : 000835 ( Main/Exploration ); précédent : 000834; suivant : 000836

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

Auteurs : Matthieu Willot ; Lea Radtke ; Daniel Könning ; Roland Fröhlich [Allemagne] ; Viktoria Gessner [Allemagne] ; Carsten Strohmann [Allemagne] ; Mathias Christmann [Allemagne]

Source :

Angewandte Chemie International Edition [ 1433-7851 ] ; 2009-11-16.

RBID : ISTEX:EAFA33461040B17E22364982C84D65293AD5672D

English descriptors

Entity :
- org : Dortmund University, Institute of Organic Chemistry Corrensstr, University of Münster.
- pers : A. E. Echavarren, A. Zhang, B. H. Brodsky, Beutler, C. D. Vanderwal, C. F. Bender, C. F. van Nostrum, C. L. Paradise, C. R. Unelius, C. Strohmann, C. W. Lee, C. W. Sigel, D. Covell, D. Hoppe, D. J. Newman, D. Könning, D. Takano, Daniel Könning, E. JimØnez, E. M. Santangelo, G. M. Cragg, H. L. Gordon, H. Matsuda, H. Song, Hans-Dieter Arndt, I. Kuwajima, I. Liblikas, J. A. Beutler, J. Becker, J. Du, J. H. van Steenis, J. Inanaga, J. K. De Brabander, J. Nat, J. Org, J. Sandell, J. Yamahara, K. Bergander, K. Chen, K. Hirata, K. Ikeda, K. Molawi, K. Mori, K. Otoguro, K. R. Chauhan, K. R. Gustafson, K. Sakurai, L. Radtke, Lea Radtke, M. C. White, M. Christmann, M. E. Krafft, M. Inoue, M. J. van Uxem, M. Leemhuis, M. S. Dowling, M. Scholl, M. Svensson, M. T. Bilodeau, M. Yoshikawa, Mathias Christmann, Mori, N. D. Litvinas, N. Murakami, N. Tanaka, P. Baeckström, P. G. Grothaus, P. S. Baran, R. Fröhlich, R. H. Grubbs, R. J. Davoile, R. M. Wilson, R. Ratnayake, Roland Fröhlich, S. Ding, S. Freeman, S. Hatakeyama, S. Kasuya, S. Omura, T. Fukuda, T. Hudlicky, T. Katsuki, T. Nagamitsu, T. R. Johnson, T. T. Ransom, U. Jacobsson, Viktoria H. Gessner, W. E. Hennink, Y. Fukuda, Y. Harigaya.
- place : Cambridge, Dortmund, Germany, Yamaguchi.
Teeft :
- Absolute configuration, Aldehyde, Angew, Angewandte chemie, Carbon framework, Chem, Danishefsky, Datum, Dortmund, Dortmund university, Englerin, Epimerization, Epoxide, Glycolate ester, Gmbh, Guaiane, Guaiane sesquiterpene englerin, Kgaa, Lett, Major isomer, Optical rotation, Rearrangement, Tetrahedron lett, Verlag, Verlag gmbh, Weinheim, Weinheim angew.

Abstract

Catnip craze: Nepetalactone, the psychoactive ingredient of catmint, was selected as starting material for the first enantioselective synthesis of englerin A. This cytotoxic guaiane sesquiterpene is a highly selective inhibitor (1–87 nM) of several renal cancer cell lines. The absolute configuration of this natural product was determined by total synthesis.

Url:

https://api.istex.fr/ark:/67375/WNG-2ZD5CJ0S-7/fulltext.pdf

DOI: 10.1002/anie.200905032

Affiliations:

Allemagne

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001369
to stream Istex, to step Curation: 001288
to stream Istex, to step Checkpoint: 000783
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to stream Main, to step Curation: 000835

Le document en format XML

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<front><div type="abstract" xml:lang="en">Catnip craze: Nepetalactone, the psychoactive ingredient of catmint, was selected as starting material for the first enantioselective synthesis of englerin A. This cytotoxic guaiane sesquiterpene is a highly selective inhibitor (1–87 nM) of several renal cancer cell lines. The absolute configuration of this natural product was determined by total synthesis.</div>
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Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri